2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-132090
    Acid-PEG3-SSPy 2088570-69-6
    Acid-PEG3-SSPy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG3-SSPy
  • HY-118781
    Propargyl-PEG3-azide 932741-18-9
    Propargyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Propargyl-PEG3-azide
  • HY-180180
    trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid
    trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid is a PROTAC linker. trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid can be used to synthesize PROTAC BLIMP-1 degrader-1 (HY-180177).
    trans-5-(4-(Hydroxymethyl)cyclohexyl)-6-methylpicolinic acid
  • HY-140608
    m-PEG3-Sulfone-PEG4-propargyl 2055041-02-4
    m-PEG3-Sulfone-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG3-Sulfone-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    m-PEG3-Sulfone-PEG4-propargyl
  • HY-W208616
    trans-4-Aminocyclohexylacetic acid 2952-00-3
    trans-4-Aminocyclohexylacetic acid is a PROTAC linker that can be used in the synthesis of PROTACs, such as PROTAC FAK degrader 4 (HY-178467).
    trans-4-Aminocyclohexylacetic acid
  • HY-141397
    m-PEG8-T-Butyl ester 2768015-32-1
    m-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG8-T-Butyl ester
  • HY-141034
    Cy5-PEG6-acid
    Cy5-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cy5-PEG6-acid
  • HY-140986
    m-PEG48-Mal 2853560-29-7
    m-PEG48-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG48-Mal
  • HY-140718
    HO-PEG5000-mal
    HO-PEG5000-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG5000-mal
  • HY-141248
    2-(Azido-PEG2-amido)-1,3-propandiol 1398044-52-4
    2-(Azido-PEG2-amido)-13-propandiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 2-(Azido-PEG2-amido)-1,3-propandiol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    2-(Azido-PEG2-amido)-1,3-propandiol
  • HY-140783
    Azido-PEG15-t-butyl ester
    Azido-PEG15-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG15-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG15-t-butyl ester
  • HY-168313
    2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine
    2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine is the PROTAC linker of KT-413 (HY-153368) and can be used in the synthesis of PROTACs.
    2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine
  • HY-138329
    THP-PEG24-THP
    THP-PEG24-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG24-THP
  • HY-W392857
    (S)-NH2-Pyridine-piperazine(Me)-Boc 1433849-58-1
    (S)-NH2-Pyridine-piperazine(Me)-Boc is a PROTAC Linker that can be used to synthesize PROTAC BTK Degrader-10 (HY-160966).
    (S)-NH2-Pyridine-piperazine(Me)-Boc
  • HY-140084
    N-(Propargyl-PEG4)-N-bis(PEG4-acid) 2093153-09-2
    N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(Propargyl-PEG4)-N-bis(PEG4-acid)
  • HY-140366
    Tos-PEG5-CH2COOtBu 1949793-62-7
    Tos-PEG5-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG5-CH2COOtBu
  • HY-134748
    HO-PEG7-CH2COOH 2250056-27-8
    HO-PEG7-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG7-CH2COOH
  • HY-140781
    Azido-PEG10-Boc 2490419-48-0
    Azido-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-Boc
  • HY-140684
    m-PEG10000-azide
    m-PEG10000-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG10000-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG10000-azide
  • HY-140080
    Gly-PEG3-endo-BCN 2354291-37-3
    Gly-PEG3-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Gly-PEG3-endo-BCN is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Gly-PEG3-endo-BCN
PROTAC Linkers Isoform Comparison

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